Organic Synthesis

Modeling Organic Chemistry and Planning Organic Synthesis

Organic Synthesis is a computationally challenging practical problem concerned with constructing a target molecule from a set of initially available molecules via chemical reactions. This paper demonstrates how organic synthesis can be formulated as a planning problem in Artificial Intelligence, and how it can be explored using the state-of-the-art domain independent planners. To this end, we d...

Optimization in organic synthesis.

Organic Synthesis, quo vadis?3 has been a phrase, perhaps in a more modern language, on the lips of the practitioners of this demanding science-art, undoubtedly from the earliest times4 but more vigorously in the last two decades.5 Comparison of achievements of yesterday6 and today7 suggests progress in our abilities to construct molecules of complexity, with higher stereocontrol, faster analys...

Microwave Assisted Organic Synthesis

DNA-Directed Organic Synthesis

Continued on page 2 DNA is the blueprint of life because of its role as the genetic material, and it plays pivotal roles in molecular biology. DNA molecules not only carry genetic information, but also serve as templates to direct the synthesis of messenger RNA, the subsequent translation enable nature to produce its highly versatile functional macromolecules, proteins, which are considered the...

Superbases for organic synthesis

"LICKOR mixtures of organolithium reagents and bulky potassium alcoholates allow the smooth metalation and subsequent electrophilic substitution of low acidity hydrocarbons, in particular olefm. The allylpotassium intermediates exhibit peculiar conformational preferences which can be exploited in novel stereoselective carbon-carbon linking reactions. A few syntheses of simple natural products i...